The study was conducted to evaluate an incinerability ranking system developed by the University of Dayton Research Institute under contract to the EPA Risk Reduction Engineering Laboratory. Mixtures of organic compounds were prepared and combined with a clay-based sorbent matrix. These mixtures were then fed into the pilot-scale rotary kiln incineration system at the U.S. EPA Incineration Research Facility. In a series of five (5) tests, the following conditions were evaluated: baseline/typical operation; thermal failure; mixing failure; matrix failure; and a worst-case combination of the three (3) failure modes. Under baseline conditions, mixing failure, matrix failure, kiln-exit destruction and removal efficiencies (DREs) for each compound were sufficiently high that separation of compounds according to observed DRE was not possible; a correlation between compound ranking and relative DRE could not be confirmed. A wider distribution of compound DREs during the thermal-failure and worst-case tests allowed for a better statistical evaluation; statistically-significant correlations above the 99% and 93% confidence intervals were identified for the two tests, respectively.