Record Display for the EPA National Library Catalog


Main Title Localization of the Mouse Thymidine Kinase Gene to the Distal Portion of Chromosome 11.
Author Hozier, J. ; Scalzi, J. ; Sawyer, J. ; Carley, N. ; Applegate., M. ;
CORP Author Florida Inst. of Tech., Melbourne. Dept. of Biological Sciences. ;Applied Genetics Labs., Inc., Melbourne, FL. ;Burroughs Wellcome Co., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/177;
Stock Number PB91-233395
Additional Subjects Chromosomes ; Thymidine kinase ; Deoxyribonucleic acids ; Mitosis ; Chromosome mapping ; Nucleic acid hybridization ; Chromosome aberrations ; Nucleic acid sequence homology ; Karyotyping ; Immunohistochemistry ; Fluorescence ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-233395 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
The authors report the cytogenetic mapping of the thymidine kinase (tk-1) gene in the mouse using two complementary and independent analyses: (1) investigation of chromosome aberrations associated with tk-1 gene inactivation in the L5178Y TK(+/-) -3.7.2C cell line, and (2) fluorescence in situ molecular hybridization of cloned tk-1 cDNA probes to mitotic chromosomes of the cell line. The consensus location from both analyses is 11E1-E2. Consideration of the mouse tk-1 gene localization, along with evidence that the homologous human TK1 gene is located distally on the large arm of chromosome 17, appears to extend the region of homology between MMU11 and HSA17 to the distal end of both chromosomes. (Copyright (c) 1991 by Academic Press, Inc.)