| Main Title |
Sister Chromatid Exchange Analysis in Lung and Peripheral Blood Lymphocytes of Mice Exposed to Methyl Isocyanate by Inhalation (Journal Version). |
| Author |
Kligerman, A. D. ;
Campbell, J. A. ;
Erexson, G. L. ;
Allen, J. W. ;
Shelby, M. D. ;
|
| CORP Author |
Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1987 |
| Year Published |
1987 |
| Report Number |
EPA-68-02-4031; EPA/600/J-87/406; |
| Stock Number |
PB89-105522 |
| Additional Subjects |
Toxic substances ;
Isocyanates ;
Cytogenetics ;
Toxicity ;
Sister chromatid exchange ;
Inhalation ;
Laboratory animals ;
Nitrogen organic compounds ;
Lung ;
Lymphocytes ;
Mitosis ;
Mononuclear leukocytes ;
Reprints ;
Methyl isocyanate ;
Isocyanato methane
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105522 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Mice were exposed to 1, 3, or 6 ppm methyl isocyanate (MIC) for 6 h/day for 4 consecutive days. Lung cells and peripheral blood lymphocytes (PBLs) were removed and cultured for analysis of sister chromatid exchange (SCE) and cell cycle kinetics. MIC caused a small but significant increase in SCE frequency of cultured lung cells from mice exposed to 1, 3, or 6 ppm MIC. MIC did not significantly increase SCE levels in PBLs of mice exposed to concentrations as high as 6 ppm. In cultured PBLs, MIC had a stimulatory effect on cell cycling rates as measured by the replicative index, and it caused a significant reduction in mononuclear leucocyte counts and the mitotic indices. (Copyright (c) 1987 Alan R. Liss, Inc.) |
