Record Display for the EPA National Library CatalogRECORD NUMBER: 4 OF 19
|Main Title||DDT Metabolism: Oxidation of the Metabolite 2,2-bis(p-Chlorophenyl)ethanol by Alcohol Dehydrogenase.|
|Author||Suggs, Joseph E. ; Hawk, Robert E. ; Curley, August ; Boozer, Elizabeth L. ; McKinney., James D. ;|
|CORP Author||Food and Drug Administration, Atlanta, Ga. Atlanta Toxicology Branch. ;National Inst. of Environmental Health Sciences, Research Triangle Park, N.C.|
|Stock Number||PB-278 089|
|Additional Subjects||DDT ; Pesticides ; Insecticides ; Toxicology ; Metabolism ; Oxidation ; Chlorine organic compounds ; Alcohols ; Reprints ; Metabolites ; Toxic substances ; Ethanol/bis(chlorophenyl) ; Dehydrogenases/alcohol|
A metabolite of DDT, 2,2-bis(p-chlorophenyl)ethanol, is a substrate of crystalline liver alcohol dehydrogenase. The oxidation of the substrate was detected spectrophotometrically. The p-nitrophenylhydrazone derivative of the product, 2,2-bis(p-chlorophenyl)acetaldehyde, was identified by comparing its mass spectrum and thin-layer chromatographic behavior with that of an authentic sample.