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Main Title Carcinogenic Risk of Non-Uniform Alpha Particle Irradiation in the Lungs: Radon Progeny Effects at Bronchial Bifurcations.
Author Hoffmann, W. ; Crawford-Brown, D. J. ; Menache, M. G. ; Martonen, T. B. ;
CORP Author NSI Technology Services Corp., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Center for Extrapolation Modelling. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. ;Salzburg Univ. (Austria). Dept. of Biophysics.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA-68-02-4450; EPA/600/J-92/313;
Stock Number PB92-227545
Additional Subjects Carcinogenesis ; Radon ; Bronchi ; Pulmonary neoplasms ; Alpha particles ; Risk assessment ; Dosimetry ; Respiration ; Air pollution effects(Humans) ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-227545 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The combined effect of enhanced deposition and reduced clearance at bronchial bifurcations leads to increased radon progeny doses within branching sites compared to uniformly distributed activity within a given airway generation. A multi-stage carcinogenesis model was used to predict the probability of lung cancer induction at different sites of the bronchial region. For relatively low radon progeny exposures, lung cancer risk is significantly higher in bifurcation zones, particularly at carinal ridges, than along tubular segments. At sufficiently high exposures, however, lung cancer risk is highest in the tubular portions of a generation. This suggests that the common assumption of a uniform dose distribution provides realistic risk estimates for high uranium miner exposures, but may underestimate lung cancer risk at low, environmental exposures. If concomitant exposure to cigarette smoke is factored into the risk analysis in a multiplicative fashion, then the effect related to risk inhomogeneity becomes even more pronounced.