Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Subchronic Inhalation of Low Concentrations of Nitrogen Dioxide. 1. The Proximal Alveolar Region of Juvenile and Adult Rats.
Author Chang, L. Y. ; Graham, J. A. ; Miller, F. J. ; Ospital, J. J. ; Crapo, J. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ., Durham, NC. Dept. of Medicine. ;Southern California Edison Co., Rosemead.
Year Published 1986
Report Number EPA/600/J-86/095;
Stock Number PB86-217270
Additional Subjects Nitrogen dioxide ; Toxicology ; Pathology ; Bioassay ; Laboratory animals ; Exposure ; Rats ; Concentration(Composition) ; Reprints ; Air pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB86-217270 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 18p
Techniques were devised to isolate tissue from the epithelium of terminal airways and the alveoli proximal to the airways. One day old juveniles and six week old adult rats were exposed to either room air or 0.5 ppm NO2 for 23 hrs per day seven days per week. An additional group of adult rats were exposed to 2.0 ppm NO2 for the same duration. Two daily hour spikes to three times the background levels (0.5 to 1.5 ppm and 2.0 to 6.0 ppm) were applied Mon. through Fri. Morphometric analysis revealed that epithelial injury occurred in all exposed animals. The juvenile rats which had been exposed to 0.5 ppm NO2 exhibited changes in the characteristics of type II epithelial cells. These cells spread to cover more alveolar surface and became thinner. Adult animals exposed to 0.5 and 2.0 ppm NO2 showed changes in alveolar macrophages and in the alveolar interstitium in addition to changes in the epithelium.