Record Display for the EPA National Library Catalog


Main Title Usefulness of 'Cyprinodon variegatus' and 'Fundulus grandis' in Carcinogenicity Testing: Advantages and Special Problems.
Author Courtney, L. A. ; Couch, J. A. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL.
Year Published 1984
Report Number EPA-600/J-84-063;
Stock Number PB84-226513
Additional Subjects Toxicology ; Bioassay ; Exposure ; Fishes ; Reprints ; Animal models ; Carcinogenesis ; Cyprinodon variegatus ; Fundulus grandis ; Water pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB84-226513 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Cyprinodon variegatus and Fundulus grandis, two species of Cyprinodontid fishes extensively studied and used in toxicological and biological investigations, are reviewed and compared as laboratory test animals. Their ecology and general biology, and suitability for various types of experimentation are examined. A laboratory system for exposing critical life stages (e.g., embryos, fry, juveniles) of these species to suspect carcinogens is described. A discussion of the use, findings and potential of these species in oncological studies and carcinogen assays is presented, particularly in regard to responses to three known or suspect carcinogen chemicals (e.g., trifluraline, benzidine, and aflatoxin). Finally, advantages and disadvantages or special problems in using the species as carcinogen test animals are reviewed.