Record Display for the EPA National Library Catalog
RECORD NUMBER: 16 OF 26| Main Title | Effects of o,p'-DDT on the Adrenal Gland and Hepatic Microsomal Enzyme System in the Beagle Dog. | |||||||||||
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| Author | Copeland, M. F. ; Cranmer., M. F. ; | |||||||||||
| CORP Author | Environmental Protection Agency, Perrine, Fla. Primate and Pesticide Effects Lab. | |||||||||||
| Year Published | 1973 | |||||||||||
| Stock Number | PB-279 721 | |||||||||||
| Additional Subjects | Insecticides ; DDT ; Pesticides ; Toxicology ; Dogs ; Enzymes ; Liver ; Ribosomes ; Adrenal gland ; Ingestion(Biology) ; Laboratory animals ; Experimental data ; Physiological effects ; Tables(Data) ; Tissues(Biology) ; Distribution ; Storage ; Adrenal cortex ; Herbicides ; Reprints ; Toxic substances ; DDD insecticide ; Bioaccumulation | |||||||||||
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| Collation | 10p | |||||||||||
| Abstract | Four male beagle dogs received o,p'-DDT (50 mg/kg/day) in corn oil, administered in gelatin capsules, for 32 days. Four dogs used as controls received only corn oil. The treated dogs maintained body weights comparable to the controls and there were no overt signs of toxicity. The treated dogs showed a decreased eosinopenic response to ACTH after day 16. There was no significant difference in the plasma sodium and potassium concentrations or in the hematocrit before or after ACTH, nor in the 17-hydroxycorticosteroid (17-OHCS) response to ACTH between the treated and control dogs on any of the test days. |