Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Cytotoxicity and mutagenesis methods for evaluating toxicity removal from wastewaters /
Author Christian, Robert. ; Cody, T.
Other Authors
Author Title of a Work
Cody, Terrence.
Bishop, Dolloff F.
CORP Author Cincinnati Univ., OH. Dept. of Environmental Health.;Environmental Protection Agency, Cincinnati, OH. Risk Reduction Engineering Lab.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Risk Reduction Engineering Laboratory,
Year Published 1989
Report Number EPA/600/2-89/011; EPA-68-03-2846; EPA 600/2-89/031
Stock Number PB89-214423
Additional Subjects Toxicity ; Mutagens ; Cytology ; Bioassays ; Sampling ; Toxicity ; Growth ; Cells(Biology) ; Public health ; Laboratory animals ; Environmental monitoring ; Sewage treatment plants ; Sewage treatment effluents ; Baseline measurements
Library Call Number Additional Info Location Last
NTIS  PB89-214423 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 68 pages ; 28 cm
The project was a feasibility study of the effectiveness of a mammalian cell cytotoxicity assay and a mammalian cell mutagenesis assay for monitoring the toxicity and mutagenicity of influent and effluent wastewater at treatment plants. In the cytotoxicity assay, ambient samples of raw sewage were substantially cytotoxic but secondary effluent samples were not toxic enough to establish an LC50 value. In the mutagenesis assays, the early Mill Creek ambient samples of raw and secondary effluent were mutagenic but the ambient samples from the later Mill Creek sampling were not mutagenic. The data suggest that the cytotoxic and mutagenic activities of the ambient waste-water samples are near the limits of detection of the two assays. When the samples had high biological activity, there was an observable response. With the exception of alkaline extracts of the second Mill Creek samples, all concentrated extracts from the samples were cytotoxic and mutagenic to some degree. The single Muddy Creek influent was not as toxic or mutagenic as the Mill Creek influent on either sampling date.
"EPA 600/2-89/031." References. "June 1989." "Dolloff F. Bishop, project officer." Microfiche.