Record Display for the EPA National Library Catalog


Main Title New Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity.
Author Clive, D. ; Caspari, W. ; Kirby, P. E. ; Krehl, R. ; Moore, M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Year Published 1986
Report Number EPA/600/D-85/284;
Stock Number PB86-152246
Additional Subjects Bioassay ; Toxicology ; Standards ; Criteria ; Cells(Biology) ; Mammals ; Mice ; Laboratory animals ; Mutagenesis
Library Call Number Additional Info Location Last
NTIS  PB86-152246 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 27p
The purpose and scope of the standard guide is to present background material and to establish criteria by which protocols and procedures for conducting the L5178Y/TK+/- -3.7.2C mouse lymphoma mutagenicity assay (MLA) can be properly understood and evaluated. These guidelines are also intended to aid researchers and others to gain a better understanding of the critical elements involved with mammalian cell mutagenicity testing. More specifically, the document is intended to provide a guide to researchers that will accomplish the following goals: Provide an understanding of the critical procedures (steps) involved in the performance of the mammalian cell mutagenicity test; Provide generalized criteria by which researchers can evaluate if they are properly performing, utilizing, and interpreting the assay; Provide criteria by which individuals responsible for evaluating mouse lymphoma mutagenicity data can determine if the experiments have been properly performed and interpreted.