Record Display for the EPA National Library Catalog


Main Title Mutagenic and Carcinogenic Potency of Diesel and Related Environmental Emissions: Salmonella Bioassay.
Author Claxton, Larry D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-646;
Stock Number PB83-243220
Additional Subjects Exhaust emissions ; Toxicology ; Bioassay ; Bacteria ; Reprints ; Diesel engine exhaust ; Air pollution effects ; Mutagenesis ; Carcinogenesis
Library Call Number Additional Info Location Last
NTIS  PB83-243220 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Due to the expected increase in the percentage of diesel vehicles in the United States, the Environmental Protection Agency must evaluate the health effects associated with exposure to diesel emissions. Respirable particles from a variety of combustion sources have the potential of being carcinogenic and mutagenic. the objective of these studies was to determine the relative biological activity of the organic material adsorbed on these particles in vitro mutagenesis bioassays. the organic extracts from the following series of emission sources were bioassayed in the Salmonella assay for mutagenic activity: (1) a light-duty Oldsmobile diesel 350 engine; (2) a heavy-duty Caterpillar diesel engine; (3) a light-duty Nissan engine; (4) a Volkswagen Rabbit diesel; (5) cigarette smoke; (6) roofing tar; (7) coke oven; and (8) a gasoline catalyst Mustang. This paper provides a comparison of these sources within the Salmonella bioassay and also demonstrates how bacterial systems can be used as a quality assurance measure in vivo testing.