Record Display for the EPA National Library Catalog
RECORD NUMBER: 17 OF 22| Main Title | Short-Term Toxicity (1 and 10 Days) of Cadmium Chloride in Male and Female Rats: Gavage and Drinking Water. | |||||||||||
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| Author | Borzelleca, J. F. ; Clarke, E. C. ; Condie., L. W. ; | |||||||||||
| CORP Author | Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div. ;Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology. | |||||||||||
| Publisher | c1989 | |||||||||||
| Year Published | 1989 | |||||||||||
| Report Number | EPA/600/J-89/462; | |||||||||||
| Stock Number | PB91-109538 | |||||||||||
| Additional Subjects | Toxicity ; Cadmium halides ; Chlorides ; Potable water ; Rats ; Body weight ; Pathology ; Testis ; Kidney ; Liver ; Lethal dosage ; Tables(Data) ; Reprints ; Health hazards ; Drug administration routes ; Organ weight ; Blood urea nitrogen ; Dose-response relationships | |||||||||||
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| Collation | 14p | |||||||||||
| Abstract | In order to assess adverse health effects caused by an event resulting in high levels of cadmium in drinking water, rats received CdCl2 by gavage or in drinking water for 1 or 10 days. The reported acute oral LD50 in rats (225 mg/kg - Kotsonis and Klaassen, 1977) was confirmed. Male and female Sprague-Dawley derived rats received CdCl2 by gavage at doses of 25, 51, 107 and 225 mg/kg body weight for 10 consecutive days. Other rats received CdCl2 solutions at concentrations of 0.014, 0.14 and 0.29 mg/ml. There were naive and vehicle controls. Compound related adverse effects were noted on body weights (decrease) and BUN. Histopathologic lesions, apparently compound related, were observed in the testis, kidney and liver of gavaged animals but not in the animals that received CdCl2 in the drinking water. |