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Main Title Methodology for Ranking the Degree of Hazard Associated with Exposure to Carcinogens and Other Toxic Chemicals.
Author Anderson, E. L. ; Chu, M. ; Dourson, M. ; DeRosa, C. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Year Published 1985
Report Number EPA/600/D-85/040;
Stock Number PB85-167906
Additional Subjects Hazardous materials ; Environmental surveys ; Public health ; Chemical compounds ; Carcinogens ; Toxicity ; Epidemiology ; Experimental design ; Metabolism ; Exposure ; Toxic substances ; Ranking ; Pharmacokinetics ; Cancer
Library Call Number Additional Info Location Last
NTIS  PB85-167906 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 57p
A hazard index is an overall indicator of the potential harm of a hazardous substance to humans and the environment. This paper describes the use of a carcinogenicity index and a systemic (chronic) toxicity index in setting reportable quantities under Section 101(14) of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980. The three types of evidence used to evaluate a substance's carcinogenic hazard are (1) epidemiological, (2) experimental and (3) supportive evidence from short-term tests, metabolism and pharmacokinetics and structure-activity correlations. Hazardous substances suspected of carcinogenic potential are ranked by the level of this evidence and the potency factor. The potency factor is /ED(sub 10), where ED(sub 10) is the estimated dose associated with a lifetime cancer risk of 10%. The toxicity index for substances with systemic (chronic) toxicity potential is based on the minimum effective dose levels for chronic exposures via environmental media and the type of effect. About 200 potential carcinogens and 200 chemicals associated with other diseases have been evaluated and assigned a hazard ranking.