Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Comparison of In vivo and In vitro Methods for Assessing the Effects of Bromobenzene on the Hepatic-Metabolizing Enzyme System.
Author Chadwick, R. W. ; Copeland, M. F. ; Carlson, G. P. ; Trela, B. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences.
Year Published 1987
Report Number EPA/600/J-87/299;
Stock Number PB88-185707
Additional Subjects Bromo organic compounds ; Enzymes ; Liver ; Chlorobenzenes ; Rats ; In vitro analysis ; In vivo analysis ; Reprints ; Bromobenzenes ; Benzene hexachloride ; Lindane
Library Call Number Additional Info Location Last
NTIS  PB88-185707 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 11p
The effect of daily i.p. injections of 0, 0.05, 0.5 and 5.0 mmol/kg bromobenzene for 1 week on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay employing lindane ( -hexachlorocyclohexane) and by a battery of in vitro enzyme assays. The data in the study indicated that repeated pretreatment with bromobenzene for 1 week stimulated a dose-related increase in phase I reactions while inducing phase II reactions at the high dose (5 mmol/kg bromobenzene). The in vivo and in vitro assays showed good agreement. (Copyright (c) Toxicology Letters, Vol. 39, 1987.)