Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Comparison of In vivo and In vitro Methods for Assessing Effects of Allyl Alcohol on the Liver.
Author Trela, B. A. ; Carlson, G. P. ; Chadwick, R. W. ; Copeland, M. F. ;
CORP Author Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-810825; EPA/600/J-85/369;
Stock Number PB86-188125
Additional Subjects Alcohols ; Liver ; Comparison ; In vivo analysis ; In vitro analysis ; Rats ; Physiological effects ; Reprints ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB86-188125 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 12p
Allyl alcohol was administered to female Fischer 344 rats at doses of 0, 3, 10 and 30 mg/kg daily for 7 days. Plasma sorbitol dehydrogenase was minimally elevated. No dose related changes were observed in hexobarbital oxidation, aniline hydroxylation, or ethylmorphine demethylation. Aldrin epoxidation was slightly elevated. Naphthol glucuronidation and glutathione-S-transferase activity with 1,2-dichloro-4-nitrobenzene were increased. Results from in vivo studies on the metabolism of lindane were in close agreement with the in vitro measurements suggesting that daily treatment for one week with allyl alcohol at doses of 3, 10 and 30 mg/kg has no significant effect on phase I pathways, a selective effect on phase II pathways and, under the conditions of this experiment, minimal hepatoxic effects in these rats.