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RECORD NUMBER: 30 OF 34

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Main Title

Utilization of the Rabbit Alveolar Macrophage and Chinese Hamster Ovary Cell for Evaluation of the Toxicity of Particulate Materials. 1. Model Compounds and Metal-Coated Fly Ash.

Author

Garrett, Neil E. ; Campbell, James A. ; Stack, H. Frank ; Waters, Michael D. ; Lewtas, Joellen ;

CORP Author

Health Effects Research Lab., Research Triangle Park, NC.

Year Published

1981

Report Number

EPA-600/J-81-098;

Stock Number

PB83-210294

Additional Subjects

Toxicology ; Fly ash ; Air pollution ; Cell cultures ; In vitro analysis ; Reprints ; Particulates

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB83-210294	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

23p

Abstract

Data are presented which detail the effects of model particulate compounds and fly ash particles on rabbit alveolar macrophage (RAM) and Chinese hamster ovary (CHO) cells. Silica, silicic acid, titanium dioxide, and size-fractionated (0,-2, 2-5, and 5-8 um) fly ash particles with and without coatings of nickel, lead, or cadmium oxides were the experimental particles. Silica was the most toxic particle studied. Cell viability and ATP in the RAM assay and colony survival in the CHO assay showed an almost identical response to silica and silicic acid.

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