||Structure-Toxicity Relationships for the Fathead Minnow, 'Pimephales promelas': Narcotic Industrial Chemicals.
Veith, G. D. ;
Call, D. J. ;
Brooke, L. T. ;
||Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies.;Environmental Research Lab.-Duluth, MN.
Lethal dosage ;
Fathead minnows ;
Pimephales promelas ;
Toxic substances ;
Water pollution effects(Animals)
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Narcosis is a reversible state of arrested activity of protoplasmic structures caused by a wide variety of organic chemicals. This nonspecific mode of toxic activity was found predominant in acute toxicity studies of industrial chemicals and fish. This paper presents 96-h LC50 values for 65 industrial chemicals including alcohols, ketones, ethers, alkyl halides, and substituted benzenes. The common mode of action permitted the development of a structure-toxicity relationship as follows: log LC50 = -0.94 log P + 0.94 log (0.000068P + 1) - 1.25 where P is the n-octanol/water partition coefficient. The data show that the toxicity of the chemicals to fish is directly comparable with the toxicity in mammals when expressed as chemical activity.