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Main Title Structure-Toxicity Relationships for the Fathead Minnow, 'Pimephales promelas': Narcotic Industrial Chemicals.
Author Veith, G. D. ; Call, D. J. ; Brooke, L. T. ;
CORP Author Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies.;Environmental Research Lab.-Duluth, MN.
Year Published 1983
Report Number EPA-R-809234; EPA-600/J-83-070;
Stock Number PB84-110006
Additional Subjects Toxicology ; Fishes ; Lethal dosage ; Mammals ; Reprints ; Fathead minnows ; Pimephales promelas ; Toxic substances ; Water pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB84-110006 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Narcosis is a reversible state of arrested activity of protoplasmic structures caused by a wide variety of organic chemicals. This nonspecific mode of toxic activity was found predominant in acute toxicity studies of industrial chemicals and fish. This paper presents 96-h LC50 values for 65 industrial chemicals including alcohols, ketones, ethers, alkyl halides, and substituted benzenes. The common mode of action permitted the development of a structure-toxicity relationship as follows: log LC50 = -0.94 log P + 0.94 log (0.000068P + 1) - 1.25 where P is the n-octanol/water partition coefficient. The data show that the toxicity of the chemicals to fish is directly comparable with the toxicity in mammals when expressed as chemical activity.