Record Display for the EPA National Library Catalog


Main Title Estimating the Acute Toxicity of Narcotic Industrial Chemicals to Fathead Minnows.
Author Veith, G. D. ; Call, D. J. ; Brooke, L. T. ;
CORP Author Environmental Research Lab.-Duluth, MN. ;Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies.
Year Published 1984
Report Number EPA-600/D-84-190;
Stock Number PB84-224450
Additional Subjects Toxicology ; Narcotics ; Estimates ; Fishes ; Screening ; Fathead minnows ; Toxic substances ; Water pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB84-224450 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
The overwhelming number of industrial chemicals either in commerce or in development precludes actual toxicity testing of each chemical and creates a need for initial screening techniques to focus efforts on those chemicals with the greatest potential for adverse environmental effects. One promising screening technique is the use of the structure-activity relationship to estimate aquatic toxicity from chemical structure. Using five major classes of industrial chemicals from the Toxic Substances Control Act (TSCA) inventory, this paper presents a structure-activity relationship between the 96-h LC50 with fathead minnows and the n-octanol/water partition coefficient which can be computed from structure. Common industrial alcohols, ketones, alkyl halides, ethers, and benzenes are shown to cause lethality by the same mode of action of narcosis. Consequently, a single bilinear equation can predict adequately the 96-h LC50 of all classes of industrial chemicals to fathead minnows.