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Main Title Effect of Chlorine Dioxide, Chlorite, and Nitrite on Mice with Low and High Levels of Glucose-6-Phosphate Dehydrogenase (G6PD) in their Erythrocytes.
Author Moore, Gary S. ; Calabrese, Edward J. ;
CORP Author Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1981
Report Number EPA-R-805557; EPA-600/1-81-014;
Stock Number PB81-152381
Additional Subjects Chlorine oxides ; Chlorites ; Nitrites ; Toxicology ; Bioassay ; Mice ; Erythrocytes ; Blood cells ; Ingestion(Biology) ; Exposure ; Phosphorus organic compounds ; Dehydrogenase/glucose phosphate ; Synergism
Library Call Number Additional Info Location Last
NTIS  PB81-152381 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 93p
Mice exposed to chlorine dioxide for 30 days at 100 ppm exhibited no significant differences from controls in any of the blood parameters measured. There were no additive or synergistic effects between chlorine dioxide and nitrite based on these same measurements. When A/J (high G6PD) and C57L/J (low G6PD) mice were exposed to various levels of sodium chlorite (0.0, 1.0, 10.0, and 100 ppm) for 30 days in their drinking water, there were a number of blood parameters that varied significantly with respect to treatment. However, with the exception of an increase in hemoglobin for the C57L/J strain at the 1.0 and 10.0 ppm level, all significant changes were associated with the 100 ppm exposure. There were no significant strain versus treatment interactions for any level of chlorite exposure.