Record Display for the EPA National Library Catalog


Main Title Reciprocal Relationship Between the Induction of delta-Aminolevulinic Acid Synthetase and Drug Metabolism Produced by m-Dichlorobenzene.
Author Poland, Alan ; Goldstein, Joyce ; Hickman, Patricia ; Burse., Virlyn W. ;
CORP Author Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Program.
Year Published 1970
Stock Number PB-279 736
Additional Subjects Drugs ; Enzymes ; Liver ; Dosage ; Metabolism ; Pharmacology ; Chlorine organic compounds ; Amino acids ; Porphyrins ; Nitrogen compounds ; Experimental data ; Rats ; Laboratory animals ; Physiological effects ; Tables(Data) ; Reprints ; Benzene/dichloro ; Synthetase/aminolevinate
Library Call Number Additional Info Location Last
NTIS  PB-279 736 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
The daily administration of large doses of m-dichlorobenzene (m-DCB) causes experimental hepatic porphyria in rats by induction of delta-aminolevulinic acid synthetase (ALA synthetase). However, smaller doses of m-DCB produce a biphasic stimulation of both urinary coproporphyrin excreation and liver ALA synthetase. The decline of ALA synthetase and urinary coproporphyrin despite continued daily dosage is associated with an increase in activity of the liver drug-metabolizing systems and decreasing serum m-DCB levels. The most probable explanation for the self-limiting action of m-DCB is stimulation by the drug of its own metabolism.