Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Carcinogenic Activity of Acrylamide in the Skin and Lung of Swiss-ICR Mice.
Author Bull, R. J. ; Robinson, M. ; Stober, J. A. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1984
Report Number EPA/600/J-84/165;
Stock Number PB85-146173
Additional Subjects Toxicology ; Skin(Anatomy) ; Mice ; Laboratory animals ; Dosage ; Reprints ; Carcinogenesis ; Acrylamide
Library Call Number Additional Info Location Last
NTIS  PB85-146173 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 6p
Doses of acrylamide ranging from 12.5 to 50 mg/kg were administered orally to female ICR-Swiss mice over a M, W & F for two weeks (total doses of 75, 150 and 300 mg/kg). Two weeks later some of the animals were begun on a promotion schedule involving the application of 2.5 micrograms TPA/mouse three times weekly. Development of tumors was observed weekly in the skin and in the lungs at one year. Acrylamide was found to initiate squamous cell adenoma and carcinomas in the skin and increased the yield of adenomas and carcinomas in the lung. Skin tumor development was dependent upon TPA promotion whereas lung tumor induction was not. These data extend previous observations of carcinogenic activity of acrylamide in the skin Sencar mice and lungs of strain A/J mice to a third strain of mouse the ICR-Swiss.