Record Display for the EPA National Library Catalog

RECORD NUMBER: 22 OF 34

OLS Field Name OLS Field Data
Main Title Formation of Mutagens Following Chlorination of Humic Acid: A Model for Mutagen Formation during Drinking Water Treatment.
Author Meier, J. R. ; Lingg, R. D. ; Bull, R. J. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1983
Report Number EPA-600/J-83-151;
Stock Number PB84-153709
Additional Subjects Water treatment ; Chlorination ; Mutagens ; Humic acids ; Potable water ; Laboratory animals ; Mathematical models ; Sampling ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB84-153709 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 18p
Abstract
Aqueous chlorination of humic acids results in the formation of compounds with direct-acting mutagenic activity in the Ames/Salmonella plate assay for tester strains TA98, TA100, TA1535, TA1537, and TA1538. The addition of a rat liver microsomal fraction (S-9) plus cofactors causes a substantial decrease of activity, the extent of which is tester strain dependent. The mutagenic activity is due predominantly to non-volatile compounds. Production of mutagens is greatly dependent on the chlorination pH, with a pattern of decreasing mutagenic activity with increasing pH. This order of activity could be at least partially explained by the alkali-liability of the compounds. Chlorination of commercial humic acids is proposed as a model for examination of mutagen formation during water chlorination.