Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Use of Short-Term Genotoxic Bioassays in the Evaluation of Unregulated Automobile Emissions.
Author Brusick, D. J. ; Young, R. R. ; Jagannath, D. R. ;
CORP Author Litton Bionetics, Inc., Kensington, MD.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-68-02-3682; EPA-600/1-84/011;
Stock Number PB84-226976
Additional Subjects Bioassay ; Exhaust emissions ; Toxicity ; Public health ; Air pollution ; Exposure ; Fuels ; Fuel additives ; Sulfur oxides ; Nitrogen oxides ; Hydrocarbons ; Carbon monoxide ; Risk ; In vitro analysis ; In vivo analysis ; Automobile exhaust ; Air pollution effects(Humans) ; Clean Air Amendments of 1977
Library Call Number Additional Info Location Last
NTIS  PB84-226976 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 127p
Exposure to fuels and fuel additives may occur through direct exposure to uncombusted fuel or fuel additive as well as to products of fuel/fuel-additive combustion. Presence of combustion products in ambient air is the major source of human exposure to motor vehicle fuels. The levels of several products of fuel combustion in ambient air (sulfur oxides, nitrogen oxides, fuel hydrocarbons and carbon monoxide) are currently regulated under the Clean Air Act Amendments (202(a)(4)) of 1977. These amendments also specify that new vehicles shall not be certified if they generate unregulated emissions which present a potential risk to human health. The objectives of this document are to review the data from selected short-term in vitro and in vivo bioassays to (a) determine if there is evidence suggesting potential human health risk either from uncombusted emissions or from emissions of combusted motor vehicle fuels or fuel additives, (b) identify the operational variables involved in generating products of concern for human health, (c) determine the probable nature of the health effects of concern, (d) estimate the ability of short-term tests to establish human risk estimates and (e) develop a short-term bioassay program to monitor the health effects of fuel/fuel additives and unregulated combustion emissions.