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Main Title Fungal Genomics [electronic resource] /
Author Brown, Alistair J.P.
Publisher Springer Berlin Heidelberg,
Year Published 2006
Call Number QH434
ISBN 9783540308096
Subjects Life sciences ; Microbiology ; Proteomics ; Microbial genetics ; Plant breeding
Internet Access
Description Access URL
Collation XVIII, 275 p. 37 illus., 6 in color. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Biocemistry and Molecular Genetics -- Metabolomics and Systems Biology in Saccharomyces cerevisiae -- Genome Evolution in Hemiascomycete Yeasts -- Investigating the Evolution of Fungal Virulence by Functional Genomics -- Fungal Rythms and Responses -- Circadian Rhythms, Photobiology and Functional Genomics in Neurospora -- Genomics of Protein Secretion and Hyphal Growth in Aspergillus -- The Genomics of Stress Response in Fission Yeast -- Programmed Cell Death and Apoptosis in Fungi -- Genomic Analysis of Cellular Morphology in Candida albicans -- Fungal Pathogenicity -- Postgenomic Approaches to Analyse Candida albicans Pathogenicity -- Integration of Metabolism with Virulence in Candida albicans -- Regulators of Candida glabrata Pathogenicity -- Using Genomics to Study the Life Cycle of Histoplasma capsulatum -- Cryptococcus neoformans Pathogenicity. Mycology, the study of fungi, originated as a subdiscipline of botany and was a descr- tive discipline, largely neglected as an experimental science until the early years of this century. A seminal paper by Blakeslee in 1904 provided evidence for sel?ncompatib- ity, termed "heterothallism", and stimulated interest in studies related to the control of sexual reproduction in fungi by mating-type speci?cities. Soon to follow was the demonstration that sexually reproducing fungi exhibit Mendelian inheritance and that it was possible to conduct formal genetic analysis with fungi. The names Burgeff, Kniep and Lindegren are all associated with this early period of fungal genetics research. These studies and the discovery of penicillin by Fleming, who shared a Nobel Prize in 1945, provided further impetus for experimental research with fungi. Thus began a period of interest in mutation induction and analysis of mutants for biochemical traits. Such fundamental research, conducted largely with Neurospora crassa,led to theone gene: one enzyme hypothesis and to a second Nobel Prize for fungal research awarded to Beadle and Tatum in 1958. Fundamental research in biochemical genetics was extended to other fungi, especially to Saccharomyces cerevisiae, and by the mid-1960s fungal systems were much favored for studies in eukaryotic molecular biology and were soon able to compete with bacterial systems in the molecular arena.