||Responses of Subjects with Chronic Obstructive Pulmonary Disease after Exposures to 0.3 PPM Ozone.
Kehrl, H. R. ;
Hazucha, M. J. ;
Solic, J. J. ;
Bromberg, P. A. ;
||North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Respiratory diseases ;
Air pollution effects(Humans) ;
Chronic obstructive lung disease
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The authors previously reported (1982) that the respiratory mechanics of intermittently exercising persons with chronic obstructive pulmonary disease (COPD) were unaffected by a 2-h exposure to 0.2 ppm ozone. Employing a single-blind cross-over design protocol, 13 white men with nonreversible COPD were randomly exposed on two consecutive days for 2 h to air and 0.3 ppm ozone. During exposures, subjects exercised for 7.5 min every 30 min; ventilation and gas exchange measured during exercise showed no difference between exposure days. Pulmonary function tests (spirometry, body plethysmography) obtained before and after exposures were unchanged on the air day.