Record Display for the EPA National Library CatalogRECORD NUMBER: 10 OF 13
|Main Title||Prediction of Carboxyhemoglobin Formation Due to Transient Exposure to Carbon Monoxide.|
|Author||Benignus, V. A. ; Hazucha, M. J. ; Smith, M. V. ; Bromberg, P. A. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. Human Studies Div. ;North Carolina Univ. at Chapel Hill.|
|Additional Subjects||Carbon monoxide ; Carboxyhemoglobin ; Air pollution effects(Humans) ; Acute exposure ; Blood chemical analysis ; Environmental health ; Biological effects ; Differential equations ; Predictions ; Statistical analysis ; Reprints ; CFKE(Coburn-Forster-Kane equation) ; Coburn-Forster-Kane equation ; Arterial carboxyhemoglobin ; Venous carboxyhemoglobin ; Arteriovenous carboxyhemoglobin difference ; Transient exposure ; HbCO(Carboxyhemoglobin)|
Fifteen men were exposed to 6,683 ppm C(18)O for 3.09-6.65 min. Arterial and antecubital vein blood samples were drawn at 1-min intervals beginning at the start of C(18)O inhalation and ending 10 min later. Simultaneously, alveolar ventilation was calculated from the measured values of minute ventilation and dead space. All other parameters of the Coburn-Forster-Kane equation (CFKE), except the Haldane affinity ratio, were measured separately in each subject. Increases in venous and arterial HbCO were inaccurately predicted during and immediately after HbCO formation. Exposure of such organs as brain or heart to carboxyhemoglobin (HbCO) may be substantially higher than expected during transient high-level CO exposure.