Record Display for the EPA National Library Catalog


Main Title Concept of Activity Profiles of Antimutagens.
Author Waters, M. D. ; Brady, A. L. ; Stack, H. F. ; Brockman, H. E. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Illinois State Univ., Normal. Dept. of Biological Sciences.
Publisher 1 Aug 89
Year Published 1989
Report Number EPA/600/D-90/037;
Stock Number PB90-220781
Additional Subjects Toxicology ; Mutagens ; Bioassay ; Free radicals ; Tables(Data) ; Salmonella typhimurium ; Reprints ; Mutagenicity tests ; Carcinogenesis ; Carcinogenicity tests ; Mutagenicity tests
Library Call Number Additional Info Location Last
NTIS  PB90-220781 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 20p
The paper will consider the use of short-term bioassays to identify antimutagenic and anticarcinogenic substances and to classify them according to the locus of their protective influence, i.e., intracellular or extracellular, and putative mechanism(s) of action. In the extracellular environment, inhibition of formation or uptake of mutagens and inactivation of promutagenic or mutagenic species are examples of antimutagenic mechanisms. Intracellularly, antimutagenic substances have been described as 'scavengers' of radicals, 'blocking agents' (involving at least 3 different mechanisms), and 'suppressing agents'. Additional intracellular mechanisms include alterations in DNA repair processes and/or modification of the genotoxic response to the mutagen/carcinogen. The presentation format will be based on the genetic activity profile (GAP) methodology developed by the authors. The GAPs of known mutagens/carcinogens will be presented together with newly designed profiles for antimutagens/anticarcinogens according to the classification scheme outlined above.