Record Display for the EPA National Library Catalog


Main Title Genetic activity profiles in the testing and evaluation of chemical mixtures /
Author Waters, M. D. ; Claxton, L. D. ; Stack, H. F. ; Brady, A. L. ; Graedel, T. E.
Other Authors
Author Title of a Work
Claxton, L. D.
Stack, H. F.
Brady, A. L.
Graedel, T. E.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;A.T. and T. Bell Labs., Murray Hill, NJ.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1989
Report Number EPA/600/D-89/147
Stock Number PB90-112780
Additional Subjects Bioassay ; Salmonella typhimurium ; Toxic substances ; Mutagenicity tests ; Carcinogenicity tests ; Data bases ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB90-112780 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 34 pages ; 28 cm
Some knowledge of the potential genetic activity of a complex environmental mixture may be gained from an assessment of the genetic activity of its component chemicals. The expanded Genetic Activity Profile (GAP) data base provides a computer-generated graphic representation of genetic bioassay data as a function of dose of the substance tested. In addition, the Atmospheric Chemical Compound (ACC) data base contains information on chemical structures, properties, detection methods and sources of chemicals found in ambient air. Using the combined data bases, information on the quantity of an individual chemical present within a mixture or fraction of a mixture may be related to the quantity (lowest effective dose, LED) of the chemical required to demonstrate a positive response in one or more genetic bioassays.
"EPA/600/D-89/147." Microfiche.