Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Subchronic Exposure to a Mixture of O3, SO2, and (NH4)2SO4 on Host Defenses of Mice.
Author Aranyi, C. ; Vana, S. C. ; Thomas, P. T. ; Bradof, J. N. ; Graham, J. A. ;
CORP Author IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-806327; EPA/600/J-83/283;
Stock Number PB85-176931
Additional Subjects Ozone ; Sulfur dioxide ; Ammonium sulfate ; Respiratory diseases ; Mice ; Laboratory animals ; Bacterial diseases ; Reprints ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB85-176931 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 19p
Mice exposed 5 h/d, 5 d/wk up to 103 d, to 0.2 mg O3/cu. m. or to a mixture of O3, 13.2 mg SO2/cu. m., and 1.04 mg (NH4)2SO4 aerosol/cu. m. showed significantly greater susceptibility to group C streptococcal aerosol infection relative to filtered air controls. Pulmonary bactericidal activity by alveolar macrophages was significantly enhanced in the lungs of mice exposed to the mixture relative to those inhaling filtered air or O3 alone. The total number and distribution of the free cells lavaged from the lungs, as well as cellular ATP levels, did not change due to the pollutant exposures. In vitro cytostasis in tumor target cells cocultured with peritoneal macrophages from the exposed mice was significantly enhanced in the O3-exposed and in the mixture-exposed treatment groups relative to controls and also in the mixture-exposed relative to the O3-exposed group when a target-to-effector-cell ratio of 1:10 was used; no such effects were observed when this ratio was 1:20. Splenic T-lymphocyte function, as measured by blastogenesis to mitogens and alloantigens, was affected by exposure to O3 and/or the mixture, although the patterns of effects were qualitatively different. Splenic B-cell function and macrophage antigen processing, as measured by the generation of antibody plaque-forming cells, was unaffected by exposure. (Copyright (c) 1983 by Hemisphere Publishing Corporation.)