||Movement of Mercury in Rat Submaxillary Slices.
Smith, Ladd W. ;
Borzelleca, Joseph F. ;
||Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The movement of HgCl2 was studied in slices of rat submaxillary gland. A steady-state distribution was reached within 60 min. N2 or metabolic inhibitors failed to decrease tissue uptake. Increasing the concentration of Hg2+ produced a corresponding increase in tissue metal. Decreasing the incubation temperature decreased uptake. Cd2+ and Fe2+ decreased uptake but Zn2+, Cu2+, and Fe3+ were without effect. Efflux experiments indicated a firm binding of Hg2+. The data suggest a passive uptake for Hg2+ with unsaturable, temperature-sensitive binding sites in the interior of the cell.