Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title In vitro and In vivo Evaluation of the Movement of Kepone in the Rat Submaxillary Gland.
Author Skalsiy, Harry L. ; Wrenn, Jacqueline M. ; Borzelleca, Joseph F. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-R-804318; EPA-600/J-80-336;
Stock Number PB82-124769
Additional Subjects Pesticides ; Toxicology ; Concentration(Composition) ; Tissues(Biology) ; Rats ; Chlorine organic compounds ; In vitro analysis ; In vivo analysis ; Reprints ; Kepone ; Submandibular gland ; Bioaccumulation
Library Call Number Additional Info Location Last
NTIS  PB82-124769 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
In vitro studies performed on slices of rat submaxillary gland showed that the rates of uptake and efflux of Kepone consisted of both a fast and a slow component. No significant alteration of these rates was observed after aeration with N2, decreased temperature, or incubations with cyanide or 2,4-dinitrophenol. In vivo data on actual concentration of Kepone in saliva and plasma over a 48 hour period showed no evidence of concentration of Kepone by the submaxillary glands. These data suggest that the movement of Kepone from blood into the saliva through the submaxillary glands occurs by means of passive diffusion.