||In vitro and In vivo Evaluation of the Movement of Kepone in the Rat Submaxillary Gland.
Skalsiy, Harry L. ;
Wrenn, Jacqueline M. ;
Borzelleca, Joseph F. ;
||Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Chlorine organic compounds ;
In vitro analysis ;
In vivo analysis ;
Submandibular gland ;
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In vitro studies performed on slices of rat submaxillary gland showed that the rates of uptake and efflux of Kepone consisted of both a fast and a slow component. No significant alteration of these rates was observed after aeration with N2, decreased temperature, or incubations with cyanide or 2,4-dinitrophenol. In vivo data on actual concentration of Kepone in saliva and plasma over a 48 hour period showed no evidence of concentration of Kepone by the submaxillary glands. These data suggest that the movement of Kepone from blood into the saliva through the submaxillary glands occurs by means of passive diffusion.