Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Excretion of Pesticides in Saliva and Its Value in Assessing Exposure.
Author Borzelleca, Joseph F. ; Skalsky, Harry L. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-R-804318; EPA-600/J-80-338;
Stock Number PB82-127895
Additional Subjects Pesticides ; Saliva ; Assessments ; Exposure ; Excretion ; In vitro analysis ; In vivo analysis ; Detection ; Insecticides ; Chlorine organic compounds ; Carbamates ; Toxicity ; Reprints ; Kepone ; Toxic substances ; Carbaryl ; Carbamic acid/methyl-(naphthyl-ester) ; Urinalysis
Library Call Number Additional Info Location Last
NTIS  PB82-127895 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 26p
The possibility that pesticides are secreted in the saliva and that this secretion can be used to assess exposure to pesticides is discussed. Both Kepone and carbaryl were tested through a series of in vitro studies and in vivo experiments including both acute and subchronic studies. In the in vivo studies, both Kepone and carbaryl were detected in the saliva in the first twenty-four hours, but seldom thereafter. Analysis of urinary samples indicated a rapid clearance of the substances from the animals. In vitro uptake and efflux studies suggested that movement of both substances was by passive diffusion and reached a plateau after 60 minutes of incubation. Efflux rates were unaffected by experimental conditions, but were ten times faster for carbaryl.