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RECORD NUMBER: 4 OF 9

OLS Field Name OLS Field Data
Main Title Excretion of Cadmium and Mercury in Rat Saliva.
Author Smith, Ladd W. ; Borzelleca, Joseph F. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-R-804318; EPA-600/J-80-335;
Stock Number PB82-124785
Additional Subjects Saliva ; Excretion ; Cadmium ; Mercury(Metal) ; Metals ; Blood pressure ; Rats ; Laboratory animals ; Reprints ;
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=2000TYR9.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB82-124785 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 9p
Abstract
The excretion of cadium and mercury in saliva was studied in urethane-anesthetized male rats given single intravenous injections of 109CdCl2 or 203HgCl2 (0.1 or 1.0 mg divalent cation/kg). Pilocarpine (20 mg/kg, ip) was used to stimulate salivation. All doses produced a distinct and persistent increase in blood pressure (15-25 mm Hg), an increase in salivary flow rate and an increase (19-26%) in salivary gland weight. Metal levels in saliva (S) and submaxillary gland tissue (T), relative to blood (B), plasma (P), and filtrate (F) were determined. Cadmium and mercury were detected in S and T at both doses. The following relative order was apparent: S/F > S/P approx. S/B. S/F ratios were > 1, suggesting a concentrating effect by the salivary gland. S/B and S/P ratios for mercury increased with increasing dose; S/B and S/P ratios for cadmium decreased with increasing dose. Similar dose-related effects were apparent in the T/B and T/P ratios.