Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Use of 'In vitro' Methods for Assessing Reproductive Toxicity, Dichlorophenols.
Author Seyler, D. E. ; East, J. M. ; Condie, L. W. ; Borzelleca, J. F. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology. ;Georgetown Univ., Washington, DC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-808861; EPA/600/J-84/127;
Stock Number PB85-113975
Additional Subjects In vitro analysis ; Toxicity ; Phenols ; Reproductive system ; Laboratory animals ; Public health ; Assessments ; Concentration(Composition) ; Chlorine organic compounds ; Dosage ; Reprints ; Phenol/dichloro
Library Call Number Additional Info Location Last
NTIS  PB85-113975 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 11p
Environmental levels of dichlorophenols (DCPs) appear to be increasing. A paucity of knowledge exists concerning the impact of these agents on human health, including reproductive effects. Mice are being exposed to various DCPs to determine their toxic potential. In addition, the mouse in vitro fertilization method ass used to evaluate the potential reproductive effects of series of DCPs. This method is preliminary reproductive screening procedure. In vitro penetration was depressed by 2,5-DCP, 3,4-DCP, and 3,5-DCP. None of the agents affected sperm motility. Acridine orange fluorescent microscopy revealed that 3,4-DCP and 3,5-DCP disrupted the sperm acrosome; this could result in depressed penetration.