Record Display for the EPA National Library Catalog

RECORD NUMBER: 9 OF 13

OLS Field Name OLS Field Data
Main Title Metabolism, Toxicity, and Carcinogenicity of Trichloroethylene.
Author Bruckner, J. V. ; Davis, B. D. ; Blancato, J. N. ;
CORP Author Environmental Monitoring Systems Lab., Las Vegas, NV. ;CH2M/Hill, Reston, VA. ;Georgia Univ., Athens. Dept. of Pharmacology and Toxicology.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/321;
Stock Number PB90-198631
Additional Subjects Toxicity ; Metabolism ; Vinyl chloride ; Kidney ; Liver ; Laboratory animals ; Reprints ; Carcinogenicity tests ; Pharmacokinetics ; Dose-response relationships
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-198631 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/27/1990
Collation 22p
Abstract
Lifetime cancer or unit risk estimates for trichloroethylene (TRI) have been calculated on the basis of metabolized dose-tumor incidence relationships. Previously, it was common practice to directly extrapolate exposure dose-tumor incidence data from laboratory animal studies to predict cancer risks in humans. Such direct species-to-species extrapolations, however, do not take into account potentially important species differences in pharmacokinetics. The consideration and use of pharmacokinetics and metabolic data can significantly reduce, though not eliminate, uncertainties inherent in species-to-species, route-to-route, and high- to low-dose extrapolations. The total amount of TRI metabolized was considered in the most recent EPA Health Assessment Document for Trichloroethylene to be the effective dose (EFD) produced tumors.