Record Display for the EPA National Library Catalog


Main Title Interim methods for development of inhalation reference doses.
Author Jarabek, A. M. ; Blackburn, K. ; Dourson, M. ; Erdreich, L. ; Overton., J. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.
Publisher Environmental Criteria and Assessment Offices, Office of Health and Environmental Assessment, U.S. Environmental Protection Agency,
Year Published 1989
Report Number EPA/600-8-88-066f; EPA/600/8-88/006F; ECAO-R-0204
Stock Number PB90-145723
OCLC Number 20771221
Subjects Health risk assessment ; Gases, Asphyxiating and poisonous--Toxicology--United States ; Air--Pollution--United States ; Inhalation
Additional Subjects Dosimetry ; Respiration ; Air pollution ; Toxicity ; Malignant neoplasms ; Extrapolation ; Tables(Data) ; Graphs(Charts) ; Exposure ; Absorption(Biology) ; Risk assessment ; Reference standards ; Health hazards ; Dose-response relationships ; Pharmacokinetics
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  TD193.5.I58 1989 Region 1 Library/Boston,MA 04/29/2016
EJBD ARCHIVE EPA 600-8-88-066F Headquarters Library/Washington,DC 10/21/2013
EJED  EPA 600/8-88-066F OCSPP Chemical Library/Washington,DC 01/12/1990
EKBD  EPA/600/8-88/066F Research Triangle Park Library/RTP, NC 12/15/1989
ERAD  EPA 600/8-88-066F Region 9 Library/San Francisco,CA 05/18/1990
ESAD  EPA 600-8-88-066F Region 10 Library/Seattle,WA 08/03/2005
NTIS  PB90-145723 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) : illustrations ; 28 cm
The document describes methodology for the derivation of Inhalation Reference Doses (RfDis). An RfDi is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a continuous lifetime inhalation exposure to the human population (including sensitive subpopulations) that is likely to be without appreciable risk of adverse noncancer health effects. A detailed discussion of factors that determine inhaled dose, including respiratory anatomy and physiology and the physiochemical properties of the inhaled pollutants, is provided. Discussions of these area included currently available information on interspecies variability. Issues related to the evaluation of study design and the generation and characterization of inhalation exposures are also discussed. Guidance on use of human data, choice of toxicity studies, application of uncertainty factors and the minimum data criteria for RfDi development is also provided.
Distributed to depository libraries in microfiche. "August 1989." Includes bibliographical references (pages 5-1-5-19). "EPA/600-8-88-066f."