| Main Title |
Interim methods for development of inhalation reference doses. |
| Author |
Jarabek, A. M. ;
Blackburn, K. ;
Dourson, M. ;
Erdreich, L. ;
Overton., J. ;
|
| CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. |
| Publisher |
Environmental Criteria and Assessment Offices, Office of Health and Environmental Assessment, U.S. Environmental Protection Agency, |
| Year Published |
1989 |
| Report Number |
EPA/600-8-88-066f; EPA/600/8-88/006F; ECAO-R-0204 |
| Stock Number |
PB90-145723 |
| OCLC Number |
20771221 |
| Subjects |
Health risk assessment ;
Gases, Asphyxiating and poisonous--Toxicology--United States ;
Air--Pollution--United States ;
Inhalation
|
| Additional Subjects |
Dosimetry ;
Respiration ;
Air pollution ;
Toxicity ;
Malignant neoplasms ;
Extrapolation ;
Tables(Data) ;
Graphs(Charts) ;
Exposure ;
Absorption(Biology) ;
Risk assessment ;
Reference standards ;
Health hazards ;
Dose-response relationships ;
Pharmacokinetics
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
TD193.5.I58 1989 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
| EJBD ARCHIVE |
EPA 600-8-88-066F |
|
Headquarters Library/Washington,DC |
10/21/2013 |
| EJED |
EPA 600/8-88-066F |
|
OCSPP Chemical Library/Washington,DC |
01/12/1990 |
| EKBD |
EPA/600/8-88/066F |
|
Research Triangle Park Library/RTP, NC |
12/15/1989 |
| ERAD |
EPA 600/8-88-066F |
|
Region 9 Library/San Francisco,CA |
05/18/1990 |
| ESAD |
EPA 600-8-88-066F |
|
Region 10 Library/Seattle,WA |
08/03/2005 |
| NTIS |
PB90-145723 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1 volume (various pagings) : illustrations ; 28 cm |
| Abstract |
The document describes methodology for the derivation of Inhalation Reference Doses (RfDis). An RfDi is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a continuous lifetime inhalation exposure to the human population (including sensitive subpopulations) that is likely to be without appreciable risk of adverse noncancer health effects. A detailed discussion of factors that determine inhaled dose, including respiratory anatomy and physiology and the physiochemical properties of the inhaled pollutants, is provided. Discussions of these area included currently available information on interspecies variability. Issues related to the evaluation of study design and the generation and characterization of inhalation exposures are also discussed. Guidance on use of human data, choice of toxicity studies, application of uncertainty factors and the minimum data criteria for RfDi development is also provided. |
| Notes |
Distributed to depository libraries in microfiche. "August 1989." Includes bibliographical references (pages 5-1-5-19). "EPA/600-8-88-066f." |
