Record Display for the EPA National Library Catalog


Main Title Effects of Trichloroethylene Exposure on Male Reproductive Function in Rats.
Author Zenick, H. ; Blackburn, K. ; Hope, E. ; Richdale, N. ; Smith, M. K. ;
CORP Author Cincinnati Univ., OH. Coll. of Medicine.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1984
Report Number EPA/600/J-84/092;
Stock Number PB84-244052
Additional Subjects Toxicology ; Exposure ; Males ; Rats ; Reprints ; Laboratory animals ; Distribution ; Metabolism ; Reprints ; Ethylene/trichloro
Library Call Number Additional Info Location Last
NTIS  PB84-244052 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
The present study was designed to evaluate the influences of trichloroethylene (TCE) on the reproductive system of male rats. In addition, information was obtained on the distribution and metabolism of TCE. At 100 days of age, male rats were allowed to copulate with ovariectomized, hormonally primed females and copulatory behaviors scored. Fifteen minutes post-ejaculation, females were sacrificed and ejaculate and semen plug recovered from the uterus and vagina for evaluation. These data served as a pre-exposure baseline for each animal. TCE exposure was then initiated with animals intubated with either 0, 10, 100, or 1000 mg/kg of TCE (10 males/group) for 5 days/week for 6 weeks. Copulatory behaviors and semen evaluations were conducted at Weeks 1 and 5 as well as 4 weeks post-exposure. Three males/group were sacrificed at the end of the sixth week of exposure and levels of TCE and its metabolites measured in various organs and blood.