Record Display for the EPA National Library Catalog


Main Title Genotoxic Properties of Municipal Wastewaters in Ohio.
Author Meier, J. R. ; Blazak, W. F. ; Riccio, E. S. ; Stewart, B. E. ; Bishop, D. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;SRI International, Menlo Park, CA.
Year Published 1987
Report Number EPA/600/J-87/214;
Stock Number PB88-170147
Additional Subjects Waste water ; Toxicology ; Ohio ; Public health ; Reprints ; Mutagenesis ; Ames test ; Salmonella assay ; Genotoxicity ; Drinking water
Library Call Number Additional Info Location Last
NTIS  PB88-170147 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Wastewaters from six municipal wastewater treatment plants in Ohio were tested at different stages of treatment for mutagenicity in the Ames/Salmonella assay. The chlorinated secondary effluents were also evaluated for induction of sister chromatid exchanges in Chinese hamster ovary cells. Direct-acting microbial mutagenicity was observed for extracts of the effluents from all six plants for both an initial and a repeat sampling series. In some cases, the mutagenicity was greatly enhanced by S9 metabolic activation (MA). In general, the specific mutagenicity of the extracts increased following activated sludge treatment. Chlorination resulted in substantial increases in mutagenic activity for some of the wastewaters but had no effect on others. SCE inducing activity was detected in five out of six extracts for the first sample series, and for two out of five extracts for the second sample series. There was no obvious correlation in the ability of the extracts from the chlorinated secondary effluents to induce SCE in GHO cells and to induce mutations in Salmonella.