Record Display for the EPA National Library Catalog
RECORD NUMBER: 3 OF 5| Main Title | Inhibition of Microsomal Metabolism and Chemical Oncogenesis in Culture by Naphthalene Quinones. | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Author | Nesnow, Stephen ; Bergman, Hinda ; Garland, Helen ; Morris, Mary ; | |||||||||||
| CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
| Year Published | 1980 | |||||||||||
| Report Number | EPA-600/J-79-149; | |||||||||||
| Stock Number | PB83-145284 | |||||||||||
| Additional Subjects | Ribosomes ; Inhibition ; Metabolism ; Liver ; Rats ; Reprints ; Oncogenesis ; Naphthalene quinones | |||||||||||
| Holdings |
|
|||||||||||
| Collation | 16p | |||||||||||
| Abstract | A series of napthalene diols, quinones, and related compounds were examined for their ability to inhibit mixed-function oxidase activities in liver microsomes obtained from rats which had been pretreated with 3-methylcholanthrene (3-MC) or phenobarbital (PB). Using benzo(a)pyrene monooxygenase as a measure of mixed-function oxidase activity, it was found that phenanthrene-9,10-quinone was the most active compound tested with a K1=0.79 uM. |