Record Display for the EPA National Library Catalog


Main Title Subchronic Toxicology of Humic Acid Following Chlorination in the Rat.
Author Condie, L. W. ; Laurie, R. D. ; Bercz, J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/399;
Stock Number PB86-201498
Additional Subjects Toxicology ; Humic acid ; Chlorination ; Rats ; Laboratory animals ; Bioassay ; Dosage ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB86-201498 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
A subchronic 90-day study was conducted with chlorinated and non-chlorinated humic acids with male Sprague-Dawley rats. Body weight gain, terminal organ and body weights, food and fluid consumption, clinical chemistries, hematological parameters, and urinalyses were determined for all animals. Selected organs were examined microscopially. Significant findings were confined to those rats given the high dose of chlorinated humic acid (1.0 g/L total organic carbon). The terminal body weight and average weekly body weight gain were significantly lower (p < 0.05) in the high dose group as compared to the distilled water control group. The difference can be partially explained by a 16% lower daily fluid consumption. The average weight of the kidneys was significantly higher in the high chlorinated humic group as compared to controls. Hematological parameters and clinical chemistry values were normal in all treatment groups. The most significant finding was the increased incidence and severity of hematuria in the high dose chlorinated humic acid group.