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Main Title Effects of Chlorine Dioxide on Thyroid Function in the African Green Monkey and the Rat (Journal Version).
Author Harrington, R. M. ; Shertzer, H. G. ; Bercz, J. P. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ. Medical Center, OH. Dept. of Environmental Health.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/479;
Stock Number PB89-105514
Additional Subjects Thyroid and antithyroid agents ; Chlorine oxides ; Water treatment chemicals ; Hormone antagonists ; Laboratory animals ; Monkeys ; Rats ; Depression ; Resilience ; Isotopic labeling ; Endocrinology ; Iodine isotopes ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-105514 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
In a previous study from the laboratory, chlorine dioxide (ClO2) treated drinking water depressed thyroxine (T4) levels in the African Green monkey. The present study again demonstrated a decrease in T4 levels in the same species after 4 weeks of oral exposure. However, after 8 weeks of treatment T4 levels rebounded to above pretreatment levels coinciding with an increase in thyroid radioiodide uptake. The T4 rebound phenomenon and increased iodide uptake may be due to a compensatory endocrinological mechanism. In rats, T4 levels dropped during the 8 week ClO2 treatment period in a dose-dependent manner, and no rebound effect was observed. Iodide uptake values in the rat were not affected. It appears that ClO2 may have an effect on thyroid parameters in both species.