Record Display for the EPA National Library Catalog


Main Title Mucociliary Clearance of Inhaled Particles Measured at 2 h after Ozone Exposure in Humans.
Author Gerrity, T. R. ; Bennett, W. D. ; Kehrl, H. ; DeWitt, P. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Human Studies Div. ;North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology.
Publisher 25 Sep 91
Year Published 1991
Report Number EPA/600/J-93/402;
Stock Number PB93-236396
Additional Subjects Ozone ; Air pollution effects(Humans) ; Toxicity ; Lung ; Respiratory function tests ; Mucus ; Air ; Comparison ; Biological transport ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-236396 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Acute exposure of humans to ozone is known to acutely cause pulmonary function decrements, inflammation, and increased permeability of pulmonary epithelium. Fifteen healthy male and female nonsmoking subjects were exposed, on different occasions, to clean air and 0.4 ppm ozone for 1 hour while they exercised continuously. Pulmonary function was measured immediately before and after exposure and 90 min and 24 hours after exposure. Each subject returned the next day for a final particle retention measurement. Despite significant changes in pulmonary function, there was no difference in mean whole lung retention time of particles between clean air and ozone exposures, indicating that mucociliary transport is unaffected by ozone exposure when it is measured 2 hours after exposure.