Record Display for the EPA National Library Catalog

RECORD NUMBER: 15 OF 15

Main Title

Toluene Levels in Blood and Brain of Rats during and after Respiratory Exposure.

Author

Benignus, Vernon A. ; Muller, Keith E. ; Barton, Curtis N. ; Brittikofer, John A. ;

CORP Author

North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.

Year Published

1981

Report Number

EPA-600/J-81-180;

Stock Number

PB83-189670

Additional Subjects

Toluene ; Bioassay ; Rats ; Laboratory animals ; Blood analysis ; Brain ; Reprints ; Air pollution effects(Animals)

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB83-189670	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

10p

Abstract

Eighty rats were exposed to 575 ppm toluene by inhalation for up to 240 min. Animals in one group were sacrificed during exposure at 15, 30, 60, 120, or 240 min. Following a 240-min exposure, groups of rats were sacrificed at 15, 30, 120, or 240 min. Blood was drawn from the vena cava of sacrified subjects. Brains were extracted and homogenized. Blood and brain tissue were assayed for toluene by gas chromatography. One-compartment pharmacokinetic models were fitted to predict toluene levels in blood and whole brain as a function of time.