| Main Title |
Skeletal Variants as an Indicator of Biological Effects of Environmental Contaminants. |
| Author |
Beck, Sidney L. ;
|
| CORP Author |
Wheaton Coll., Norton, MA. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1981 |
| Report Number |
EPA-R-805420; EPA-600/1-81-034; |
| Stock Number |
PB81-186025 |
| Additional Subjects |
Toxicology ;
Teratogens ;
Mice ;
Musculoskeletal system ;
Contaminants ;
Exposure ;
Examination ;
Detection ;
Bioindicators ;
Biological effects ;
Toxic substances ;
Environmental health ;
Teratogenesis ;
Prenatal
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB81-186025 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
213p |
| Abstract |
The skeletal variant assay system (SVAS) explores the possible detection of subtle biological effects of in utero exposure to noxious substances. This was attempted even in the absence of gross malformations by an examination of a series of variations in development of adult skeletons. Several pesticides and a number of known teratogens were among the tested compounds. When necessary, toxicity tests were performed. Eighty-eight variants were selected for the study, using CD-1 mice. Prenatal studies included fetal skeletal parameters to provide comparability to teratogen studies. |
