Record Display for the EPA National Library Catalog


Main Title Technical analysis of new methods and data regarding dichloromethane hazard assessments /
Author Bayard, S. ; Bayliss, D. L. ; Blancato, J. N. ; Bloom, M. ; Cohn, M.
CORP Author United States. Environmental Protection Agency. Office of Research and Development.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment,
Year Published 1987
Report Number EPA/600/8-87/029A
Stock Number PB87-228557
OCLC Number 16521821
Subjects Environmental health
Additional Subjects Environmental health ; Hazardous materials ; Toxicology ; Epidemiology ; Bioassay ; Screening ; Toxicity ; Chlorine organic compounds ; Metabolism ; Methane/dichloro ; Carcinogenesis ; Pharmacokinetics
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-8-87-029A Headquarters Library/Washington,DC 09/30/2011
EJED  EPA/600/8-87/029A OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD  EPA-600/8-87-029A Research Triangle Park Library/RTP, NC 01/01/1988
ESAD  EPA 600-8-87-029A Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB87-228557 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xiii, 155 p. : ill. ; 28 cm.
New information on cytotoxicity, genotoxicity, and epidemiology has raised some questions about the federal regulatory agencies' cancer risk assessments for dichloromethane (DCM, methylene chloride). In addition, physiologically based pharmacokinetic models have been developed, showing that tissue-level delivery of metabolically activated DCM may be disproportionately reduced at low exposure levels. These studies suggest to some that the clear carcinogenic response seen in mice under chronic high exposures does not imply substantive human risk at low doses. The Health/Risk Assessment Committee (HRAC), comprising representatives of four federal regulatory agencies, was convened to conduct joint analyses of these new data. The document reports on the HRAC's consideration of the data and the questions they raise about human cancer risk from DCM. It serves as a source of up-to-date analyses that may be drawn upon by each agency as it considers modifying its cancer risk assessment. The HRAC finds that, despite new data, the mechanism of carcinogenic action of DCM remains problematical; there is no basis at present to conclude that carcinogenic response is unique to mice or confined to high exposure levels.
"EPA/600/8-87/029A." "June 1987." "Review draft."