Record Display for the EPA National Library Catalog


Main Title Teratology of a zineb fo[r]mulation /
Other Authors
Author Title of a Work
Short, Robert D.
Baron, Ronald L.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1980
Report Number EPA-600/1-80-017; EPA-68-02-2982
Stock Number PB80-181175
OCLC Number 47899442
Subjects Fungicides--Research. ; Fungicides--Toxicology.
Additional Subjects Toxicology ; Fungicides ; Congenital abnormalities ; Rats ; Mice ; Laboratory animals ; Ingestion(Biology) ; Dosage ; Pregnancy ; Toxic substances ; Teratogenesis ; Zineb ; Ethylenebis(dithiocarbamates) zinc
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHBD  EPA-600/1-80-017 CEMM/ACESD Library/Narragansett,RI 03/16/2007
EJBD ARCHIVE EPA 600-1-80-017 Headquarters Library/Washington,DC 01/30/2012
EJBD  EPA 600-1-80-017 Headquarters Library/Washington,DC 04/24/2014
EKBD  EPA-600/1-80-017 Research Triangle Park Library/RTP, NC 09/07/2001
NTIS  PB80-181175 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vi, 19 p. ; 28 cm.
The purpose of the present study was to evaluate the teratogenic potential of a zineb formulation. An initial toxicity study indicated that oral doses of 1,000 or 2,000 mg/kg/day adversely affected the weight gain of nonpregnant rats but not nonpregnant mice. In the teratology study pregnant rats and mice received daily oral doses of 0, 200, 632, or 2,000 mg/kg from day 6 of gestation until the day before C-section. Maternal welfare, as monitored by body weight and food consumption, was affected only in rats that received 2,000 mg/kg/day of the formulation. Evidence of embryo or fetal lethality was not present in rats or mice. However, fetuses from rats that received 2,000 mg/kg/day of the formulation had a reduced body weight. Some anomalies were significantly increased in rats that received 2,000 mg/kg/day of the formulation. These anomalies included hydrocephalus, split centra, incompletely ossified frontal bones, and enlarged occipital fontanel. None of the anomalies observed in mice were increased to a statistically significant level in any of the groups treated with the formulation. This study indicated that the zineb formulation produced anomalies in rats at doses which adversely affected maternal welfare. In addition, there was no evidence of teratogenicity in mice treated with similar doses.
EPA Project Officer: Ronald L. Baron. Prepared by Midwest Research Institute for U.S. Environmental Protection Agency. "February 1980." Includes bibliographical references (p. 18). "EPA-600/1-80-017."