Record Display for the EPA National Library Catalog


Main Title Dietary subacute toxicity of ethylenebisisothiocyanate sulfide in the laboratory rat /
Author Freudenthal, Ralph I.
Other Authors
Author Title of a Work
Baron, Ronald L.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1976
Report Number EPA-600/1-76-030; EPA-68-02-1717
Stock Number PB 259 915
OCLC Number 42836766
Subjects Fungicides--Physiological effect.
Additional Subjects Fungicides ; Toxicity ; Sulfur heterocyclic compounds ; Nitrogen heterocylics with 2N ; Pesticides ; Degradation ; Thyroid gland ; Neoplasms ; Malignant neoplasms ; Pathology ; Physiological effects ; Paralysis ; Thyroid hormones ; Histology ; Sublethal dosage ; Ingestion(Biology) ; Toxic tolerances ; Rats ; Laboratory animal ; Bioassay ; Permissible dosage ; Imidazodithiazole thione/dihydro ; Cancer ; Histopathology
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-76-030 Headquarters Library/Washington,DC 04/27/2012
EJBD  EPA 600-1-76-030 Headquarters Library/Washington,DC 04/08/2014
EKBD  EPA-600/1-76-030 Research Triangle Park Library/RTP, NC 06/06/2003
ELBD  EPA 600-1-76-030 AWBERC Library/Cincinnati,OH 08/26/2016
NTIS  PB-259 915 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation iv, 28 pages : illustrations ; 28 cm.
Ethylenebisisothiocyanate sulfide (EBIS) was fed to groups of rats at 0, 1, 10, 100, and 1000 ppm for up to 90 days. Only those rats receiving EBIS at 1000 ppm demonstrated a toxic response to the test chemical reflected as a reversible paralysis of the hind legs noted within 8 to 14 days. If left on the 1000 ppm diet, the animals soon died. When removed from the diet, the animals recovered, only to become ataxic on further dietary exposure at the high level. No histologic lesion could be identified in either H & E or luxol fast blue stained sections of the brain, spinal cord, or peripheral nerves from the paralyzed animals. The ability to reverse the paralysis by removing the animals from the test diet coupled with the lack of histologically observable lesions adds credence to a proposed biochemical lesion. Ingestion of 1000 ppm EBIS for 7 days also resulted in measurable changes in thyroid function. A no effect level for this 90 day dietary study for EBIS is 100 ppm in the diet, equivalent to an average intake ranging from 67 mg/kg body weight at week 1 to 31 mg/kg body weight at week 12.
"EPA-600/1-76-030." "Contract no. 68-02-1717." "Project officer, Ronald L. Baron." Includes bibliographical references (page 27).