Record Display for the EPA National Library Catalog


Main Title Synaptonemal Complex Analysis in Genetic Toxicology.
Author Backer, L. C. ; Moses, M. J. ; Allen, J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.
Publisher 1989
Year Published 1989
Report Number EPA/600/D-89/155;
Stock Number PB90-119249
Additional Subjects Genetics ; Mice ; Genetic radiation effects ; Cells(Biology) ; Meiosis ; Synaptonemal complex ; Sex chromosome abnormalities ; Dose-response relationships ; Karyotyping
Library Call Number Additional Info Location Last
NTIS  PB90-119249 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Synaptonemal complex analysis provides a unique means of visualizing the behavior of meiotic chromosomes. The technique has been applied to the study of normal karyotypes and mutant stocks of mice. Recent work demonstrating the usefulness of SC analysis for the detection of chromosome damage suggests its potential application in a variety of mechanistic and applied studies. Studies investigated cell-stage specific damage included by radiation and expressed as SC and/or metaphase chromosome aberrations. Radiation was found to exhibit a similar stage-specific clastogenic activity for SCs as it does for meiotic metaphase chromosomes. The nature of the chromosome damage detected depend upon the cell stage exposed and on the endpoint harvested for analysis.