||Effects of manganese and their modification by hexametaphosphate /
Bull, Richard J.
||Health Effects Research Lab., Cincinnati, Ohio. Water Quality Div.
|| Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Trace elements in animal nutrition. ;
Trace elements in annimal nutrition
Laboratory animals ;
Experimental data ;
Potable water ;
Water supply ;
Water treatment ;
Physiological effects ;
Nervous system disorders ;
Inorganic phosphates ;
Environmental health ;
Water pollution effects(Humans) ;
Maximum permissible exposure level ;
Threshold limit values ;
Occupational safety and health ;
Toxic tolerances ;
||CEMM/GEMMD Library/Gulf Breeze,FL
||Some EPA libraries have a fiche copy filed under the call number shown.
||20 pages ; 28 cm.
The ability of oral Mn(+2) to produce the depletions of dopamine in the corpus striata characteristic of the Parkinson-like syndrome in manganese workers was examined in rats. A second objective of this work was to study the biological interactions between Mn(+2) and sodium hexametaphosphate ((NaPO3)6) administered simultaneously in drinking water. The authors conclude that Mn(+2) in drinking water presents little hazard in terms of central nervous system involvement in a homogeneous population. The involvement of genetic factors which have been suggested to account for the sporadic occurrence of Parkinson-like symptoms in Mn(+2) workers can not be excluded. The use of (NaPO3)6 for Mn(+2) complexation as an alternative to removal in drinking water treatment appears safe from a health standpoint if carefully controlled to avoid excessive amounts of (NaPO3)6.